Key result
Dual drug therapy with enalapril and carvedilol significantly improved cardiac function in a 10-year-old female manifesting carrier of muscular dystrophy with left ventricular dysfunction.
Why the study?
Does dual drug therapy with enalapril and carvedilol improve cardiac function in a pediatric female manifesting carrier of muscular dystrophy with left ventricular dysfunction?
Case Report (n=1)
Does dual drug therapy with enalapril and carvedilol improve cardiac function in a pediatric female manifesting carrier of muscular dystrophy with left ventricular dysfunction?
Left ventricular myocardial dysfunction may occur during childhood in female carriers of dystrophinopathies and can improve with ACE inhibitor and beta-blocker therapy.
Answers are grounded in this paper and cite their sources.
May support dual therapy in symptomatic pediatric carriers; hypothesis-generating and requires prospective confirmation before practice change.
Duchenne muscular dystrophy and Becker muscular dystrophy are X-linked disorders that result from a mutation in the dystrophin gene that reduces the production or effectiveness of the protein dystrophin. These disorders are clinically characterized by progressive muscle degeneration. Manifesting female carriers are generally not identified as such until after puberty, when symptoms such as muscle weakness may arise. This clinical report describes a female manifesting carrier who started to show deterioration of left ventricular systolic function, but no marked skeletal muscle weakness, at the age of 10 years. The patient's cardiac function improved significantly after dual drug therapy with an ACE inhibitor (enalapril) and a beta-blocker (carvedilol). Our case adds to the existing evidence that left ventricular myocardial dysfunction may occur during childhood in female carriers of dystrophinopathies.
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Martinez et al. (2011) conducted a case report in Left ventricular dysfunction in a female manifesting carrier of muscular dystrophy (n=1). Dual drug therapy with an ACE inhibitor (enalapril) and a beta-blocker (carvedilol) was evaluated on Cardiac function improvement. Dual drug therapy with enalapril and carvedilol significantly improved cardiac function in a 10-year-old female manifesting carrier of muscular dystrophy with left ventricular dysfunction.
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