Population
Isolated sarcoplasmic reticulum, anesthetized open-chest dogs, and isolated rabbit atrial and perfused…
Design
Preclinical
Follow-up
up to 7-9 hours
Authors
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Sustained pressor effect in canine shock; leaves open translation to human therapy and requires prospective trials.
RO 2-2985 is a positive inotropic agent that significantly increases ventricular contractile force and blood pressure in animal models, suggesting potential therapeutic applications.
Schwartz et al. (1974) studied this question.
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