Key result
Substitution of rat chromosome 3 from the resistant BN strain onto the SS background significantly attenuated radiation-induced cardiotoxicity compared to the parental SS rat strain.
Why the study?
The underlying causes and biomarkers of radiation-induced cardiotoxicity are currently unknown, requiring experimental models with inherent differences in sensitivity and resistance to its development.
Population
Parental SS (Dahl salt-sensitive/Mcwi) and SS-3 BN consomic rats
Comparison
SS rat strain vs SS-3 BN consomic rat strain
Design
Preclinical animal model study
Follow-up
1 wk postradiation
Authors
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Hypothesis-generating for genetic loci modulating radiation cardiotoxicity; leaves open human translation pending validation.
Heritable genetic factors on rat chromosome 3, including the Nrf2 pathway, can modify sensitivity to radiation-induced cardiotoxicity.
Schlaak et al. (2019) studied Radiation-induced cardiotoxicity. Substitution of rat chromosome 3 from BN strain onto SS background (SS-3 BN consomic) vs. SS (Dahl salt-sensitive/Mcwi) rat strain was evaluated on Radiation-induced cardiotoxicity (survival, pleural and pericardial effusions, echocardiogram parameters, and histological damage). Substitution of rat chromosome 3 from the resistant BN strain onto the SS background significantly attenuated radiation-induced cardiotoxicity compared to the parental SS rat strain.
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