Key result
Lisinopril modified cardiovascular remodeling and enhanced survival from 41% to 86% (p = 0.0013) in rats following 13-Gy partial-body irradiation.
Why the study?
Total-body irradiation causes multiorgan toxicity mitigated by ACE inhibitors, prompting investigation into post-radiation echocardiographic features before and after pneumonitis and the actions of lisinopril.
Does lisinopril improve echocardiographic features and survival in female rats exposed to 13-Gy partial-body irradiation?
Population
Female WAG/RijCmcr rats at 11-12 wk of age
Comparison
13-Gy partial-body irradiation with or without lisinopril vs nonirradiated controls with or without lisinopril
Design
Animal study across four experimental groups
Follow-up
100 d
Authors
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Lisinopril merits human trials for radiation cardioprotection; leaves open efficacy beyond rodent models.
Does lisinopril improve echocardiographic features and survival in female rats exposed to 13-Gy partial-body irradiation?
Absolute Event Rate: 86% vs 41%
p-value: p=0.0013
Lisinopril mitigated early radiation-induced pulmonary hypertension and modified cardiovascular remodeling, significantly improving survival in a rat model of partial-body irradiation.
Jacobs et al. (2019) studied Radiation pneumonitis and irradiation-induced toxicity. Lisinopril vs. Irradiation without lisinopril was evaluated on Survival (p=0.0013). Lisinopril modified cardiovascular remodeling and enhanced survival from 41% to 86% (p = 0.0013) in rats following 13-Gy partial-body irradiation.
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