Key result
Captopril ameliorated capillary function indices and fibrosis but failed to prevent the progressive functional deterioration of rat hearts after long-term irradiation.
Why the study?
Does captopril prevent late radiation-induced cardiac pathology in rats?
Does captopril prevent late radiation-induced cardiac pathology in rats?
Captopril improves some histological markers of radiation-induced cardiac damage in rats but does not prevent progressive functional deterioration.
Captopril improves some histological markers but not function in irradiated rat hearts; leaves open any role for ACE inhibition in human radiation cardiotoxicity.
The aim of this study was to test the efficacy of captopril, an angiotensin-converting enzyme inhibitor and a known suppressor of fibrosis, in preventing late radiation-induced cardiac pathology. Myocardial functional, histochemical and ultrastructural-morphometric studies were done on perfused hearts of rats isolated 3 and 6 months after 60Co gamma irradiation with 20 Gy and age-matched controls. At each time the animals were divided into the following groups: nonirradiated controls; irradiated once with 20 Gy; irradiated as above and given daily doses of captopril; daily doses of captopril without irradiation. The results showed that captopril, while ameliorating the decrease in the indices of capillary function, increase in mast cells, fibrosis, number of atrial granules, and changes in nerve terminals, failed to prevent the progressive functional deterioration of the hearts after irradiation. These findings suggest that an intramyofiber derangement may be involved in the long-term myocardial complications of irradiation.
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Harper et al. (1993) studied Late radiation-induced cardiac pathology. Captopril vs. Irradiated without captopril, nonirradiated controls, and captopril without irradiation was evaluated on Myocardial functional, histochemical and ultrastructural-morphometric changes. Captopril ameliorated capillary function indices and fibrosis but failed to prevent the progressive functional deterioration of rat hearts after long-term irradiation.
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