Effects of quinapril, a new angiotensin converting enzyme inhibitor, on left ventricular failure and survival in the cardiomyopathic hamster. Hemodynamic, morphological, and biochemical correlates.

CHF 146 cardiomyopathic (CM) hamsters (an idiopathic model of congestive heart failure) and age-matched Golden Syrian (GS) hamsters as normal controls

Quinapril administered in drinking water at average daily doses of 10.2, 112.4, and 222.4 mg/kg/day (for left ventricular performance assessment) or 100 mg/kg/day (for survival assessment) starting at 180 days of age

Vehicle-treated or untreated CM hamsters and GS hamsters

Left ventricular failure (in vitro left ventricular contractile performance, coronary flow, left ventricular volume) and survivalhard clinical