Key result
CIED-related tricuspid regurgitation is linked to ~2-fold higher mortality risk across device patients.
Why the study?
Implantation of CIEDs may cause or worsen tricuspid regurgitation, requiring multidisciplinary management to summarize its epidemiology, clinical presentation, and treatment.
This review synthesizes the mechanisms, multimodal diagnostic imaging, and emerging transcatheter, surgical, and leadless pacing strategies for managing CIED-related tricuspid regurgitation via a multidisciplinary heart team.
Cardiac implantable electronic devices (CIEDs) have been increasingly used in the management of various rhythm disorders amidst an aging population with more prevalent cardiovascular comorbidities. Although generally well-tolerated and safe, implantation of CIEDs may result in or worsen tricuspid regurgitation (TR), which is associated with a higher risk of morbidity and mortality. Several mechanisms of TR following device implantation have been proposed, and multiple diagnostic tests, percutaneous and surgical interventions, and alternative pacing methods have been developed to address this. CIED-related TR thus requires a multidisciplinary team of experts in cardiac imaging, interventional cardiology, electrophysiology, and cardiothoracic surgery with a comprehensive understanding of this multifaceted disease. The objective of this review is to summarize the epidemiology, clinical presentation, and management of CIED-related TR.
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Aldaas et al. (2024) conducted a review in Cardiac implantable electronic device (CIED)-related tricuspid regurgitation. Multidisciplinary management of CIED-related tricuspid regurgitation (including medical therapy, transvenous lead extraction, percutaneous transcatheter interventions, surgery, and alternative valve-sparing pacing strategies) was evaluated. CIED-related tricuspid regurgitation affects 5% to 40% of device patients, conferring a 1.6- to 2.5-fold increased mortality risk and requiring multidisciplinary management.
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