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Cancer cells possess a unique metabolic phenotype, rewiring their metabolic pathways to support energy-intensive and biosynthetic requirements for exuberant proliferation and migration. Attention has focused on the role of microRNAs (miRNAs) in mediating metabolic shifts in cancer cells. miRNAs participate in cancer metabolism reprogramming mainly by directly silencing the expression of specific genes. This review focuses on miRNA regulation of cancer metabolic reprogramming, including glucose, fatty acid and amino acid metabolism, and allows a deeper understanding of importance of miRNAs in tumorigenesis and progression, therefore, providing new avenues for cancer therapy strategy.
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Ding et al. (2022) studied this question.
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