Key result
Higher body mass index was significantly associated with an increased intramyocellular lipid-to-creatine ratio and decreased lipid unsaturation in skeletal muscle.
Why the study?
Does the degree of lipid unsaturation and lipid compartment size measured by 2-D MRS correlate with BMI in healthy males?
Cross-Sectional (n=24)
Does the degree of lipid unsaturation and lipid compartment size measured by 2-D MRS correlate with BMI in healthy males?
Absolute Event Rate: 13.1% vs 5.9%
p-value: p=<0.01
Two-dimensional MRS can noninvasively quantify skeletal muscle lipid compartments and reveals that intramyocellular lipid increases and lipid unsaturation decreases with higher BMI.
Should not yet change clinical practice; leaves open prognostic value of 2-D MRS lipid measures in obesity.
The link between body weight, lipid metabolism, and health risks is poorly understood and difficult to study. Magnetic resonance spectroscopy (MRS) permits noninvasive investigation of lipid metabolism. We extended existing two-dimensional MRS techniques to permit quantification of intra- and extramyocellular lipid (IMCL and EMCL, respectively) compartments and their degree of unsaturation in human subjects and correlated these results with body mass index (BMI). Using muscle creatine for normalization, we observed a statistically significant (P < 0.01) increase in the IMCL-to-creatine ratio with BMI (n = 8 subjects per group): 5.9 +/- 1.7 at BMI < 25, 10.9 +/- 1.82 at 25 < BMI < 30, and 13.1 +/- 0.87 at BMI > 30. Similarly, the degree of IMCL unsaturation decreased significantly (P < 0.01) with BMI: 1.51 +/- 0.08 at BMI < 25, 1.30 +/- 0.11 at 25 < BMI < 30, and 0.90 +/- 0.14 at BMI > 30. We conclude that important aspects of lipid metabolism can be evaluated by two-dimensional MRS and propose that degree of unsaturation measured noninvasively may serve as a biomarker for lipid metabolic defects associated with obesity.
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Velan et al. (2008) conducted a cross-sectional in Obesity (n=24). Body mass index (obesity/overweight) vs. Normal-weight (BMI 18-24.9) was evaluated on Intramyocellular lipid (IMCL)-to-creatine ratio (p=<0.01). Higher body mass index was significantly associated with an increased intramyocellular lipid-to-creatine ratio and decreased lipid unsaturation in skeletal muscle.
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