Key result
Among statin users, South Asian and African-Caribbean individuals were significantly more likely to report depression compared to White Europeans (OR 2.00 and OR 2.96, respectively).
Why the study?
Is statin use associated with depression differently across ethnic groups in a UK population?
Population
1,333 adults from a population-based tri-ethnic study, mean age 70 years, 77% male, based in the UK.
Comparison
Statin use vs No statin use
Design
Cross-sectional
Authors
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May suggest ethnic differences in statin-related depression; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=1,333)
Is statin use associated with depression differently across ethnic groups in a UK population?
Odds Ratio: 2 (95% CI 1.25–3.21)
p-value: p=0.041
Statin use may be associated with increased depressive symptoms in South Asian and African-Caribbean populations compared to White Europeans, highlighting the need for diverse representation in statin trials.
Williams et al. (2015) conducted a cross-sectional in Depression (n=1,333). Statin use vs. White European statin users / Non-users was evaluated on Depression (score ≥4/10 on the ethnically-validated Geriatric Depression Scale) (OR 2.00, 95% CI 1.25-3.21, p=0.041). Among statin users, South Asian and African-Caribbean individuals were significantly more likely to report depression compared to White Europeans (OR 2.00 and OR 2.96, respectively).
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