Why the study?
Does baseline Doppler echocardiography predict major cardiovascular events during high-dose Interleukin-2 administration in patients with metastatic cancer?
Population
19 patients with metastatic renal cell carcinoma or malignant melanoma.
Design
Cohort
Follow-up
4 days (immediately after infusion)
Authors
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An abnormal basal E/A ratio was associated with higher IL-2 withdrawal rates; this observational link is hypothesis-generating and requires prospective validation.
Does baseline Doppler echocardiography predict major cardiovascular events during high-dose Interleukin-2 administration in patients with metastatic cancer?
Baseline Doppler echocardiography, specifically an E/A ratio < 1.0, may predict major cardiovascular toxicity and the need for treatment withdrawal in patients receiving high-dose Interleukin-2.
Citterio et al. (1996) studied this question.
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