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May 1, 2001Medicine & Science in Sports & Exercise

Is Body Fatness or Its Distribution Related to Endothelial Function in Older Persons?

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Why the study?

Is central obesity associated with reduced endothelium-dependent flow-mediated vasodilatation in mildly hypertensive older persons?

Population

36 mildly hypertensive but otherwise healthy adults (14 men, 22 women), aged 55 to 75 years (mean 62.9 ± 5.2).

Design

Cross-sectional

Authors

JDJ R. DeRegisMerck (Japan)KTKatherine TurnerUniversity of MichiganABAnita C. BacherAssistance Publique – Hôpitaux de Paris

Discussion

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Implication

Central obesity may flag endothelial dysfunction risk in older hypertensives; leaves open whether reducing visceral fat improves function.

Structured PICO

Is central obesity associated with reduced endothelium-dependent flow-mediated vasodilatation in mildly hypertensive older persons?

P
Population
36 mildly hypertensive but otherwise healthy adults (14 men, 22 women), aged 55 to 75 years (mean 62.9 ± 5.2).
O
Outcome
Endothelium-dependent flow-mediated vasodilatation (FMD) measured as the percent change of brachial artery diameter at 1-minute of reactive hyperemiasurrogate

In older persons, indices of central obesity such as visceral adipose tissue and waist-hip ratio are predictive of endothelial dysfunction, whereas total fatness shows little association.

Cite This Study

DeRegis et al. (2001) studied this question.

synapsesocial.com/papers/6a73201ce9250f204eacb805https://doi.org/10.1097/00005768-200105001-01737
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Also Consider

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  5. 5The relationship of visceral adiposity with endothelial functions and subclinical atherosclerosis in obese individuals2024 · 3 citations