Key result
Computer simulation demonstrated that blood pressure buffering and baroreflex sensitivity are unrelated unless coupled gains in all baroreflex limbs are assumed.
Computer simulations suggest that blood pressure buffering and baroreflex sensitivity are unrelated, implying that the clinical benefit of high BRS is likely due to vagal effects on the heart rather than effective BP buffering.
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Challenges assumption that BRS benefits stem from BP buffering; hypothesis-generating for vagal cardiac effects requiring prospective validation.
Vooren et al. (2006) studied Heart failure and healthy subjects. Various randomly chosen combinations of feedback gains in the baroreflex arms was evaluated on BP resonance, BP-buffering capacity, and BRS. Computer simulation demonstrated that blood pressure buffering and baroreflex sensitivity are unrelated unless coupled gains in all baroreflex limbs are assumed.
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