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April 30, 2018PLoS PathogensOpen Access

Immunophenotypic characterization of CSF B cells in virus-associated neuroinflammatory diseases

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Key result

Antibody secreting B cells were significantly elevated in the cerebrospinal fluid of patients with HAM/TSP (83.87%) and relapsing-remitting multiple sclerosis (100%) compared to healthy donors (0%).

Population

Patients with HTLV-1-associated myelopathy/tropical spastic paraparesis, healthy normal donors, and subjects…

Design

Cross-sectional

Authors

YEYoshimi Enose‐AkahataNational Institutes of HealthSAShila AzodiNational Institutes of HealthBSBryan SmithNational Institute of Neurological Disorders and Stroke

Discussion

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Implication

May implicate intrathecal B-cell activity in HAM/TSP and MS; hypothesis-generating from case-control data and should not yet change practice.

Study Design

Type

Cross-Sectional (n=170)

Multicenter

Yes

Structured PICO

P
Population
170 subjects including patients with HAM/TSP, multiple sclerosis, HIV, PML, asymptomatic HTLV-1 carriers, and healthy donors evaluated for cerebrospinal fluid B cell and T cell immunophenotypes.
C
Comparator
Healthy normal donors and subjects with other chronic virus infection and/or neuroinflammatory diseases
O
Outcome
B cell and T cell immunophenotypes in CSFsurrogate

Main Result

Absolute Event Rate: 83.87% vs 0%

p-value: p=<0.0001

Elevated antibody secreting B cells and CD4+CD25+ T cells in the CSF of HAM/TSP patients suggest a role for the B cell compartment in controlling viral persistence or driving disease development.

Limitations

  • Small sample size for certain subgroups, such as asymptomatic carriers and primary progressive MS patients
  • Cross-sectional design limits the ability to establish causal relationships between B cell/T cell interactions and disease development

Cite This Study

Enose‐Akahata et al. (2018) conducted a cross-sectional in Virus-associated neuroinflammatory diseases (HAM/TSP, MS, PML, HIV) (n=170). Virus-associated neuroinflammatory diseases (HAM/TSP, RRMS, PML) vs. Healthy normal donors and asymptomatic carriers was evaluated on Presence of antibody secreting B cells (ASCs) in cerebrospinal fluid (p=<0.0001). Antibody secreting B cells were significantly elevated in the cerebrospinal fluid of patients with HAM/TSP (83.87%) and relapsing-remitting multiple sclerosis (100%) compared to healthy donors (0%).

synapsesocial.com/papers/6a73257857d56039052c19e1https://doi.org/10.1371/journal.ppat.1007042
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An inverse correlation of HTLV-I viral load in CSF and intrathecal synthesis of HTLV-I antibodies in TSP/HAM1999 · 31 citations
  2. 2Patterns of cerebrospinal fluid pathology correlate with disease progression in multiple sclerosis2001 · 249 citations
  3. 3IL-21 and IL-21 Receptor Expression in Lymphocytes and Neurons in Multiple Sclerosis Brain2011 · 149 citations
  4. 4B Cell–attracting Chemokine 1, a Human CXC Chemokine Expressed in Lymphoid Tissues, Selectively Attracts B Lymphocytes via BLR1/CXCR51998 · 862 citations