Monitoring the Reaction Progress in Combinatorial Chemistry: ¹H MAS NMR Investigations on Single Macro Beads in the Suspended State

Laborious cleavage and isolation steps are avoided! The method of 1 H magic angle spinning (MAS) NMR spectroscopy can be used to monitor the course of the synthesis on a single resin particle in a suspended sample in the nanoliter detection range. This extremely useful technique for combinatorial chemistry was tested on a hydantoin reaction sequence.