Key result
Saffold virus is an emerging human cardiovirus associated with diverse clinical symptoms, though human studies on its pathogenicity have been confounded by coinfections.
This review highlights the emerging role of Saffold virus, a ubiquitous cardiovirus associated with diverse systemic symptoms, emphasizing the need for robust molecular and animal research to clarify its pathogenicity.
No immediate clinical implications for cardioviral testing; leaves open Saffold virus pathogenicity pending studies addressing coinfection confounders.
Saffold virus (SAFV) is an emerging human cardiovirus that has been shown to be ubiquitous. Initial studies of SAFV focused on respiratory and gastrointestinal infection; however, it has also recently been associated with diverse clinical symptoms including the endocrine, cardiovascular, and neurological systems. Given the systemic nature of SAFV, and its high prevalence, understanding its pathogenicity and clinical impact is of utmost importance. This comprehensive review highlights and discusses recent developments in epidemiology, human pathogenicity, animal, and molecular studies related to SAFV. It also provides detailed insights into the neuropathogenicity of SAFV. We argue that human studies have been confounded by coinfections and therefore require support from robust molecular and animal research. Thereby, we aim to provide foresight into further research to better understand this emerging virus.
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Tan et al. (2016) conducted a review in Saffold virus infection. Saffold virus was evaluated. Saffold virus is an emerging human cardiovirus associated with diverse clinical symptoms, though human studies on its pathogenicity have been confounded by coinfections.
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