Key result
A whole genome screen using DNA pooling identified 10 markers associated with multiple sclerosis, confirming susceptibility regions at 6p, 17q, 19q, and 1p, and identifying novel sites at 1q, 2p, and 4q.
Population
Multiple sclerosis cases, controls and trio families
Design
Case-control
Authors
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These MS loci require independent replication; extends susceptibility mapping but leaves open causal and clinical relevance.
Case-Control (n=2,670)
A whole genome screen using DNA pooling confirmed multiple sclerosis susceptibility associations with regions previously linked to the disease, including 6p, 17q, 19q, and 1p, while identifying novel sites.
Sawcer et al. (2002) conducted a case-control in Multiple sclerosis (n=2,670). Genetic variants vs. Controls and unaffected parents was evaluated on Genetic association with multiple sclerosis. A whole genome screen using DNA pooling identified 10 markers associated with multiple sclerosis, confirming susceptibility regions at 6p, 17q, 19q, and 1p, and identifying novel sites at 1q, 2p, and 4q.
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