Amantadine-induced diastolic depolarization and automaticity in ventricular muscle.
Why the study?
Does amantadine alter the electrophysiological properties and induce automaticity in isolated ventricular muscle preparations?
Population
Isolated ventricular muscle preparations from frog, rabbit, cat, dog, and calf
Comparison
Amantadine hydrochloride (100-800 microM) vs Baseline/washout (absence of drug)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Amantadine induces automaticity in isolated ventricular muscle; leaves open its utility as an in vitro model for arrhythmia mechanisms.
Structured PICO
Does amantadine alter the electrophysiological properties and induce automaticity in isolated ventricular muscle preparations?
P
Population
Isolated ventricular muscle preparations from frog, rabbit, cat, dog, and calf
I
Intervention
Amantadine hydrochloride (100-800 microM)
C
Comparator
Baseline/washout (absence of drug)
O
Outcome
Changes in electrophysiological properties (action potential duration, amplitude, maximum diastolic potential, and phase 4 depolarization)surrogate
Amantadine directly alters the membrane properties of ventricular muscle, inducing diastolic depolarization and automaticity, which may serve as a model for studying cellular mechanisms of ventricular rhythm disturbances.
Cite This Study
Salata et al. (1982) studied this question.