Key result
Systematic alignment of VP1 sequences of human rhinovirus prototype strains revealed that previously proposed crucially important amino acids in receptor footprints were not conserved in a receptor group-specific way.
Population
Capsid protein VP1 sequences of all human rhinovirus (HRV) prototype strains
Design
Preclinical
Authors
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Challenges prior rhinovirus receptor models; leaves open functional validation needs in future structural studies.
Systematic sequence alignment of related virus strains can test hypotheses from molecular studies and generate ideas for future research on virus structure and replication.
Laine et al. (2005) studied Human rhinovirus. Alignment of capsid protein VP1 sequences was evaluated on Conserved motifs in the primary structure. Systematic alignment of VP1 sequences of human rhinovirus prototype strains revealed that previously proposed crucially important amino acids in receptor footprints were not conserved in a receptor group-specific way.
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