Key result
Smoking and diabetes during pregnancy provoked significant changes in ophthalmic artery perfusion, indicating vasoconstriction and hypoperfusion compared to healthy controls (p≤0.000).
Why the study?
Do diabetes and smoking alter ophthalmic artery perfusion indices in pregnant women compared to healthy pregnancies?
Observational (n=236)
Do diabetes and smoking alter ophthalmic artery perfusion indices in pregnant women compared to healthy pregnancies?
Smoking and diabetes during pregnancy are associated with significant changes in ophthalmic artery perfusion, indicating vasoconstriction and hypoperfusion.
Suggests heightened vascular surveillance in diabetic pregnant smokers; leaves open prognostic value of ophthalmic perfusion changes.
The aims of this study are to characterize the ophthalmic artery (OA) perfusion in smoker pregnant ladies, diabetic pregnant ladies and smoker diabetic pregnant ladies using Doppler indices and to compare with normal healthy pregnancy. The sample was divided into 4 groups: group 1 were normal healthy pregnant ladies (N=57) , group 2 were smokers pregnant ladies (N=44) ,group 3 were diabetic pregnant ladies (N=64),and group 4 were diabetic smoke pregnant ladies (N=71) ladies. All groups were examined and assessed during the pregnancy period for OA Doppler indices of both right and left eyes. The resistive index (RI), pulsatility index (PI), and mean velocity (MV) were determined. Comparisons were performed between the norms and the other three groups. Result showed significant increasing in RI,PI in the right and left eyes in all groups at p0.000 except in smoker pregnant ladies p 0.069 , the PI decreased in the third trimester,as well the MV decreased significantly with advancing GA. A significant differences were detected between norms and the three groups at p0.000 In conclusion, Doppler velocimetry is an acknowledged technique for evaluation of the RI, PI, and MV in the OA. Regarding the results smoking provokes perfusion changes in ophthalmic artery in smoker pregnant ladies. Thus, there are signs of an OA vasoconstriction and hypoperfusion . OA blood flow velocity was decreased in diabetic pregnant ladies.
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Ahmed et al. (2016) conducted an observational in Pregnancy (diabetes and smoking) (n=236). Smoking and diabetes vs. Normal healthy pregnancy was evaluated on Ophthalmic artery Doppler indices (Resistivity index, pulsatility index, and mean velocity) (p=≤0.000). Smoking and diabetes during pregnancy provoked significant changes in ophthalmic artery perfusion, indicating vasoconstriction and hypoperfusion compared to healthy controls (p≤0.000).
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