Key result
T1D in pregnancy is linked to a ~63% higher ophthalmic artery resistive index.
Why the study?
Doppler indices of the ophthalmic artery in pregnant women with type 1 diabetes were not well characterized compared to healthy pregnant and non-pregnant controls.
Do ophthalmic artery Doppler indices differ in pregnant women with type 1 diabetes compared to healthy pregnant and non-pregnant controls?
Observational (n=44)
Do ophthalmic artery Doppler indices differ in pregnant women with type 1 diabetes compared to healthy pregnant and non-pregnant controls?
Absolute Event Rate: 1.3% vs 0.8%
p-value: p=<.005
Type 1 diabetes during pregnancy is associated with significantly altered ophthalmic artery hemodynamics, characterized by increased resistive and pulsatility indices and decreased mean velocity.
Should not change pregnancy management in type 1 diabetes; hypothesis-generating for vascular monitoring and needs prospective validation.
This Study aimed to assess the Doppler indices for ophthalmic artery in type 1diabetic pregnant ladies. Inclusion criteria were 15diabetic pregnant ladies, their ages were (30-39), 14 healthy pregnant non diabetic ladies aged (30-37), and 15 healthy non pregnant non diabetic subjects aged (30-41) were selected as control group. Pregnant ladies with eye disease or pregnancy abnormality or preeclampsia were excluded. Ultrasound examination for both eyes were obtained using 7.5MHZ high resolution ultrasound machine. Readings of Ophthalmic artery Doppler indices (resistive index (RI), pulsatility index (PI)) for type 1 diabetes ladies were found to be greater when compared with the control group values and Mean Velocity (MV) was of lower values. The mean values ± SD were as follows: for right eye: resistive index, 1.3 ± 0.2 (P < .005 Control0.8 ± 0.1); pulsatility index, (3.6 ± 0.4 (P < .005Control1.6 ± 0.4); Mean Velocity (MV) 5.2 ± 1.1(P < .005 Control 8.4 ± 3.2). For left eye resistive index, 1.4 ± 0.2 (P < .005 Control 0.7 ± 0.1); pulsatility index, 3.3 ± 0.5 (P < .005Control 1.6 ± 0.3); Mean Velocity (MV) 5.7 ± 0.8 (P < .005 Control 8.5 ± 3.2). The correlations between the variables and gestational age in the two pregnant groups were studied and were compared with the control group and maternal treatment. The study revealed that the Doppler indices for right and left eyes differed significantly within the three trimesters for pregnant diabetic and pregnant non diabetic ladies and when compared with the control group at p-value ˂0.05. No significant difference was detected between the Doppler indices and the treatment taken as Diet Control, or insulin for type 1 diabetic pregnant ladies. Color Doppler Ultrasonography is useful for assessing blood flow. Ophthalmic arteries Doppler Indices were affected significantly in pregnant ladies with or without type 1diabetes.
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Gehan Abdelhaleim Abdelhaleim Ahmed (2014) conducted an observational in Type 1 diabetes during pregnancy (n=44). Type 1 diabetes during pregnancy vs. Healthy pregnant and non-pregnant non-diabetic controls was evaluated on Right eye resistive index (RI) (p=<.005). Type 1 diabetes during pregnancy was associated with significantly higher ophthalmic artery resistive index (1.3 vs 0.8, P<0.005) compared to healthy controls.
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