Key result
A two-month course of Melitor (25 mg daily) significantly reduced depression levels, improved cerebral blood circulation, and harmonized brain electrogenesis in patients with ischemic post-stroke depression.
Why the study?
Does agomelatine improve depressive symptoms, cerebral hemodynamics, and brain bioelectrical activity in patients with post-stroke depression?
Observational (n=30)
Does agomelatine improve depressive symptoms, cerebral hemodynamics, and brain bioelectrical activity in patients with post-stroke depression?
Agomelatine treatment for two months in patients with post-stroke depression significantly improves depressive symptoms, daily living activities, and cerebral hemodynamics.
Does not support changing post-stroke depression care; Level 5 data leaves open efficacy in randomized trials.
This paper presents the results of the effects of Melitor (25 mg during two months) on the psychic-emotional state, cerebral hemodynamic and bioelectrical activity of the brain in 30 patients (average age 66.2 ± 3.2 years) with ischemic post-stroke depression. It has been found that this drug possesses a multimodal action which is characterized by the decrease of the level of depression, widening of the range of social-environmental activity, improvement of the cerebral blood circulation and harmonization of the brain electrogenesis. In the patients with right versus left hemisphere stroke, the effect of Melitor on the functional state of the brain was more pronounced. Based on the results obtained in our study, we can recommend Melitor to use it in complex scheme of rehabilitation care of patients of the given nosological category.
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Victor V. Kuznetsov (2018) conducted an observational in Ischemic post-stroke depression (n=30). Melitor (Agomelatine) vs. Baseline (before treatment) was evaluated on Hamilton depression scale score. A two-month course of Melitor (25 mg daily) significantly reduced depression levels, improved cerebral blood circulation, and harmonized brain electrogenesis in patients with ischemic post-stroke depression.
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