Key result
The term 'insulin dysregulation' is a misnomer for hyperinsulinaemia in horses and should be abandoned in favor of 'insulin resistance', as evidence for dysregulation without resistance is weak.
The term 'insulin dysregulation' in horses with hyperinsulinaemia is argued to be a misnomer and should be abandoned in favor of 'insulin resistance'.
Summary For the last 10 years, the term ‘insulin dysregulation’ has replaced ‘insulin resistance’ when referring to horses with hyperinsulinaemia. The rationale was that this was an all‐inclusive term that covered all possible causes of hyperinsulinaemia. The implication is that hyperinsulinaemia has been shown to occur outside of insulin resistance; with insulin resistance being defined as failure of the insulin‐sensitive cells to respond normally to insulin, as best documented by the euglycaemic hyperinsulinaemic clamp. This article will show the evidence for that is weak to nonexistent in the horse and the term ‘insulin dysregulation’ is a misnomer that should be abandoned.
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Eleanor M Kellon (2024) conducted a review in Hyperinsulinaemia in horses. Insulin dysregulation terminology vs. Insulin resistance terminology was evaluated. The term 'insulin dysregulation' is a misnomer for hyperinsulinaemia in horses and should be abandoned in favor of 'insulin resistance', as evidence for dysregulation without resistance is weak.
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