A Randomized Clinical Trial of Asymmetric Anisometropic Correction for Anisometropic Amblyopia in Children Aged 4 to 12 Years

Method: 210 participants with anisometropic amblyopia (40 to 80 letters, approximately 20/50 to 20/320). Eligible participants (mean age 7.4 years, mean baseline visual acuity of 65 letters, mean baseline interocular acuity difference of 4.15 0.96 lines) were randomly assigned to treatment for 24-months with asymmetric hyperopic correction (n = 105) or full amblyopic eye hyperopic correction (n = 105). Change in amblyopic-eye visual acuity from baseline to 3, 6, 12 and 24-month, assessed by a masked examiner until visual acuity stabilized or amblyopia resolved.