Key result
Women with pregnancy-induced hypertension had significantly higher mean uterine artery resistivity index (0.64 vs 0.50, P<0.0001) and systolic/diastolic ratio than normotensive controls.
Why the study?
Doppler ultrasound is routinely used to evaluate accessible vessels, prompting an evaluation of its clinical usefulness in the uterine artery in women with pregnancy-induced hypertension.
Are uterine artery Doppler indices abnormal in women with pregnancy-induced hypertension compared to normotensive pregnant women?
Case-Control (n=400)
Are uterine artery Doppler indices abnormal in women with pregnancy-induced hypertension compared to normotensive pregnant women?
Absolute Event Rate: 0.64% vs 0.5%
p-value: p=<0.0001
Uterine artery Doppler indices, including resistivity index and systolic/diastolic ratio, are significantly elevated in pregnancy-induced hypertension and may be useful for clinical evaluation.
May support Doppler assessment in pregnancy-induced hypertension; leaves open prognostic value and therapeutic implications.
Background: Pregnancy-induced hypertension (PIH) is a syndrome of hypertension with or without proteinuria, occurring when systolic blood pressure is greater than or equal to 140 mmHg and diastolic blood pressure is greater than or equal to 90 mmHg at gestational age of 20 weeks and above in a woman who has been previously normotensive. Doppler ultrasound (DUS) is now routinely used for evaluation of accessible vessels, hence its clinical application in patients with PIH. Aims and Objective: To evaluate the usefulness of DUS of the uterine artery (UA) in women with PIH. Materials and Methods: This was a prospective case–control study in which ultrasound examination of the uterus of 400 patients (200 hypertensive and 200 normotensive pregnant women) was performed. The UA Doppler indices, resistivity index, and systolic/diastolic ratio (RI and SD/DV) were recorded. Results: The mean RI in the PIH group (0.64 ± 0.07) was significantly higher than the mean of 0.50 ± 0.06 among the control group (t = 19.922, df = 398; P < 0.0001). In addition, the mean SD/DV ratio was significantly higher in the PIH group (3.04 ± 0.67) than in the control group (2.09 ± 0.29) (t = 18.270, df = 398; P < 0.0001). The Doppler spectral waveform patterns of the UA in both the groups revealed the presence of diastolic notch in 81.5% of the patients with PIH but in none of the control patients (Fisher’s exact P < 0.0001). Conclusion: Doppler parameters of the UA are abnormal in PIH, and its predictive value in PIH would be useful in the management of such patients.
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Saleh et al. (2019) conducted a case-control in Pregnancy-induced hypertension (n=400). Pregnancy-induced hypertension vs. Normotensive pregnancy was evaluated on Uterine artery resistivity index (RI) (p=<0.0001). Women with pregnancy-induced hypertension had significantly higher mean uterine artery resistivity index (0.64 vs 0.50, P<0.0001) and systolic/diastolic ratio than normotensive controls.
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