Key result
In isolated guinea-pig ventricular heart cells, 10 mM caffeine drastically reduced Q(OFF) on repolarization to -50 mV in a time- and voltage-dependent manner, likely due to Ca2+ release from the SR.
Population
Isolated guinea-pig ventricular heart cells
Design
Preclinical
Authors
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May link SR Ca2+ release to Ca2+-induced I_Ca inactivation; hypothesis-generating in isolated myocytes.
Caffeine affects intramembrane charge movements in ventricular cells likely via calcium release from the sarcoplasmic reticulum, which may contribute to calcium-induced inactivation of the calcium current.
Leroy et al. (2002) studied Isolated guinea-pig ventricular heart cells. Caffeine was evaluated on Intramembrane charge movements (ICM). In isolated guinea-pig ventricular heart cells, 10 mM caffeine drastically reduced Q(OFF) on repolarization to -50 mV in a time- and voltage-dependent manner, likely due to Ca2+ release from the SR.
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