Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 1978Circulation ResearchOpen Access

Action of caffeine on calcium transport by isolated fractions of myofibrils, mitochondria, and sarcoplasmic reticulum from rabbit heart.

View Full Paper
Ask AI
Bookmark
Share

Population

Subcellular organelles (myofibrils, mitochondria, and sarcoplasmic reticulum) isolated from rabbit myocardium

Design

Preclinical

Authors

LBLynda BlayneyHTH. R. ThomasJMJohn Muir

Discussion

Loading...

Member takes

Overview

Hypothesis-generating for caffeine effects on myocardial calcium handling; leaves open translation to human arrhythmia risk or practice.

Structured PICO

P
Population
Subcellular organelles (myofibrils, mitochondria, and sarcoplasmic reticulum) isolated from rabbit myocardium
I
Intervention
Caffeine (various concentrations, e.g., 20 mM)
O
Outcome
Calcium transport and accumulationsurrogate

This preclinical study demonstrates that caffeine impairs calcium accumulation in the sarcoplasmic reticulum of rabbit myocardium by increasing membrane permeability to calcium.

Cite This Study

Blayney et al. (1978) studied this question.

synapsesocial.com/papers/6a7bed2e351d91d38cc63e12https://doi.org/10.1161/01.res.43.4.520
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influence of Caffeine and Other Inotropic Interventions on the Onset of Unloaded Shortening Velocity in Mammalian Heart Muscle1973 · 18 citations
  2. 2Tetanic contraction in mammalian cardiac muscle1971 · 26 citations
  3. 3Influence of caffeine on force development and force-frequency relations in cat and rat heart muscle1974 · 60 citations
  4. 4Effects of caffeine on the intracellular distribution of calcium in frog sartorius muscle1971 · 20 citations