Competition and redistribution among calcium transport systems in rabbit cardiac myocytes
Population
Rabbit ventricular myocytes
Comparison
Sequential blockade of calcium transport systems… vs Normal twitch relaxation
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Redundant Ca2+ removal mechanisms ensure rapid relaxation; hypothesis-generating for diastolic dysfunction but requires human validation.
Structured PICO
P
Population
Rabbit ventricular myocytes
I
Intervention
Sequential blockade of calcium transport systems (sarcoplasmic reticulum, Na/Ca exchange, mitochondrial uptake, sarcolemmal pump) using caffeine, 0Na/0Ca solution, FCCP + oligomycin, and 0Na/10Ca solution
C
Comparator
Normal twitch relaxation
O
Outcome
Myocyte shortening and [Ca]i transients (relaxation t1/2)surrogate
This preclinical study delineates the relative contributions and interactions of the sarcoplasmic reticulum, Na/Ca exchanger, mitochondria, and sarcolemmal calcium pump in regulating intracellular calcium during cardiac myocyte relaxation.
Cite This Study
Bers et al. (1993) studied this question.