Why the study?
Does caffeine affect Na(+)-K+ ATPase activity and contractile activity in rat heart preparations?
Population
Rat heart sarcolemmal preparations and isolated perfused rat hearts
Comparison
Caffeine (0.1-10 mM) vs Absence of caffeine
Design
Preclinical
Authors
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No immediate clinical implications for caffeine use; hypothesis-generating for sarcolemmal Na-K ATPase modulation of contractility.
Does caffeine affect Na(+)-K+ ATPase activity and contractile activity in rat heart preparations?
Caffeine exerts biphasic effects on Na(+)-K+ ATPase activity and contractility in rat hearts, suggesting the cardiac sarcolemma as a site of action.
Gupta et al. (1990) studied this question.