Why the study?
Does caffeine alter electrical and mechanical events in dog ventricular myocardial fibers through calcium-dependent mechanisms?
Population
Ventricular myocardial fibers of the dog in vitro
Comparison
Different concentrations of caffeine under… vs Control conditions
Design
Preclinical
Authors
Loading...
No immediate clinical implications; leaves open translation of calcium effects to human ventricular function.
Does caffeine alter electrical and mechanical events in dog ventricular myocardial fibers through calcium-dependent mechanisms?
Caffeine enhances cellular calcium in ventricular myocardial fibers, which mediates its electrical and mechanical effects such as increased contractile force and altered action potential plateau.
Mario Vassalle (1984) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: