September 1, 1985AJP Heart and Circulatory Physiology

Relationship between caffeine effects and calcium in canine cardiac Purkinje fibers

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Population

Canine cardiac Purkinje fibers perfused in vitro

Comparison

Caffeine (1-9 mM) vs Control conditions and various modified conditions

Design

Preclinical

Authors

MVMario VassalleState University of New York

Discussion

Member takes

Implication

May prompt caution with caffeine in arrhythmia-prone patients; leaves open translation from canine Purkinje fibers to humans.

Structured PICO

Population

Canine cardiac Purkinje fibers perfused in vitro

Intervention

Caffeine (1-9 mM)

Comparator

Control conditions (absence of caffeine) and various modified conditions (local anesthetics, tetrodotoxin, high potassium, low sodium, veratridine, metabolic inhibitors)

Outcome

Electrical and mechanical events (repolarization, plateau, terminal phase 3, force of contraction, oscillatory potentials)surrogate

Caffeine induces a marked delay in final repolarization in canine Purkinje fibers through a calcium-modulated process, likely related to electrogenic sodium-calcium exchange.

Cite This Study

Mario Vassalle (1985) studied this question.

synapsesocial.com/papers/6a8835192d13770579f4e02f https://doi.org/10.1152/ajpheart.1985.249.3.h520

View Full Paper

Ask AI

Bookmark

Relationship between caffeine effects and calcium in canine cardiac Purkinje fibers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Relationship between caffeine effects and calcium in canine cardiac Purkinje fibers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider