Role of calcium in caffeine-norepinephrine interactions in cardiac Purkinje fibers.

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Population

Canine cardiac Purkinje fibers perfused in vitro

Comparison

Caffeine or theophylline with or without… vs Absence of caffeine or norepinephrine

Design

Preclinical

Authors

Discussion

Does not support clinical changes in arrhythmia management; hypothesis-generating for norepinephrine effects on calcium handling in cardiac tissue.

Population

Canine cardiac Purkinje fibers perfused in vitro

Intervention

Caffeine (0.5-9 mM) or theophylline (0.5-1 mM) with or without norepinephrine (0.5-10 microM)

Comparator

Absence of caffeine or norepinephrine

Outcome

Contractile force and action potential repolarizationsurrogate

In canine cardiac Purkinje fibers, norepinephrine modulates caffeine-induced contractile changes by altering cytoplasmic calcium dynamics.

Satoh et al. (1989) studied this question.

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Does not support clinical changes in arrhythmia management; hypothesis-generating for norepinephrine effects on calcium handling in cardiac tissue.