Key result
In canine cardiac Purkinje fibers, norepinephrine initially diminishes caffeine-induced cytoplasmic calcium overload and subsequently enhances it by increasing the slow inward current.
Population
Canine cardiac Purkinje fibers perfused in vitro
Comparison
Caffeine or theophylline with or without… vs Absence of caffeine or norepinephrine
Design
Preclinical
Authors
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May warrant caution with methylxanthines during catecholamine surges; leaves open translation from canine Purkinje fibers.
In canine cardiac Purkinje fibers, norepinephrine modulates caffeine-induced cytoplasmic calcium overload through biphasic effects on sarcoplasmic reticulum calcium uptake and slow inward current.
Satoh et al. (1989) studied this question. Caffeine and norepinephrine was evaluated on Contractile force and action potential repolarization. In canine cardiac Purkinje fibers, norepinephrine initially diminishes caffeine-induced cytoplasmic calcium overload and subsequently enhances it by increasing the slow inward current.
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