Key result
Hypertension, systolic blood pressure, and albuminuria, but not RAS gene polymorphisms, were strongly associated with middle cerebral artery stenosis in asymptomatic Chinese type II diabetic patients.
Why the study?
Are conventional risk factors and RAS gene polymorphisms associated with middle cerebral artery stenosis in asymptomatic Chinese type II diabetic patients?
Case-Control (n=707)
Are conventional risk factors and RAS gene polymorphisms associated with middle cerebral artery stenosis in asymptomatic Chinese type II diabetic patients?
In asymptomatic Chinese type II diabetics, conventional risk factors like blood pressure and albuminuria, rather than RAS gene polymorphisms, are associated with middle cerebral artery stenosis.
Answers are grounded in this paper and cite their sources.
Supports hypertension and albuminuria monitoring in asymptomatic diabetics; leaves open RAS polymorphism relevance for stenosis.
BACKGROUND: Conventional and genetic risk factors have been reported to play a role in the pathogenesis of ischaemic stroke, and differences may explain the heterogeneity of disease presentation in different populations. In Chinese, middle cerebral artery (MCA) stenosis is the most commonly identified intracranial vascular lesion. The involvement of renin-angiotensin system (RAS) gene polymorphisms in this condition has not been determined. OBJECTIVES: To determine whether conventional and RAS genetic vascular risk factors are associated with MCA stenosis, asymptomatic Chinese type II diabetic patients with and without MCA stenosis matched for age, gender and diabetes duration were compared. METHODS: Biochemical parameters and the genotype and allele frequencies of three RAS gene polymorphisms, the angiotensin-converting enzyme (ACE) insertion/deletion, angiotensinogen (AGT) M235T and angiotensin II type 1 receptor (AT(1)R) A1166C polymorphisms were then compared between 217 diabetics with and 490 matched diabetic controls without MCA stenosis selected from 2,202 diabetics. RESULTS: MCA stenosis was associated with significantly increased systolic blood pressure, LDL-cholesterol and albuminuria, yet diastolic blood pressure and glucose levels were lower. There was an increased prevalence of hypertension and use of blood pressure-lowering agents in the MCA stenosis patients. Albuminuria was also more commonly found in these patients. Hypertensive status, systolic blood pressure and albuminuria were strong, independent predictors of the presence of MCA stenosis. No differences in the RAS polymorphism distributions were observed between patients with and without MCA stenosis. CONCLUSIONS: In these asymptomatic type II diabetics, blood pressure indices and albuminuria, but not RAS gene polymorphism, were closely associated with MCA stenosis.
No takes yet. Share an insight, caveat, or question.
Thomas et al. (2003) conducted a case-control in Type II Diabetes and Middle Cerebral Artery Stenosis (n=707). Conventional risk factors and RAS gene polymorphisms vs. Diabetic patients without MCA stenosis was evaluated on Presence of MCA stenosis. Hypertension, systolic blood pressure, and albuminuria, but not RAS gene polymorphisms, were strongly associated with middle cerebral artery stenosis in asymptomatic Chinese type II diabetic patients.
Synapse has enriched 10 related papers. Consider them for comparative context: