October 1, 1987Biochemical JournalOpen Access

Pig kidney angiotensin converting enzyme. Purification and characterization of amphipathic and hydrophilic forms of the enzyme establishes C-terminal anchorage to the plasma membrane

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Population

Pig kidney angiotensin converting enzyme (ACE)

Design

Preclinical

Authors

Discussion

No immediate clinical implications from this animal study; leaves open structural insights for ACE-targeted research.

Population

Pig kidney angiotensin converting enzyme (ACE)

Intervention

Solubilization with Triton X-100, trypsin, endogenous activity, or Triton X-100 with EDTA (10 mM)

Outcome

Characterization of amphipathic and hydrophilic forms of ACE and determination of membrane anchoragesurrogate

This basic science study establishes that angiotensin converting enzyme is anchored to the plasma membrane via its C-terminus.

Hooper et al. (1987) studied this question.

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