Study of integral indices for diagnosing insulin resistance in horses Authors

Since insulin resistance is a component of the pathogenesis of many diseases, including the development of metabolic syndrome, its detection and elimination should be considered as an important and necessary means of preventing diseases and their complications. Unlike many complex methods, the data of integral indices are the main ones for detecting insulin resistance disorders. Thus, the aim of the work was to diagnose insulin resistance in horses using homeostatic indices and to establish their practical significance. For the study, 18 horses were used, which were divided into 2 groups according to the scoring of physical condition, which was carried out by two independent veterinary specialists. The calculation of integral indices: HOMA-IR index, HOMA-β index, Caro index, metabolic index, atherogenicity index was performed according to the literature. It was found that the HOMA-β index and the HOMA-IR index were significantly increased by 18.1% (p<0.01) and 3.7 times (p<0.01) compared to the control; Caro index in horses with insulin resistance was reduced by 39.4% (p<0.05); metabolic index increased by 82.5% (p<0.01); atherogenicity index in horses with insulin resistance was 54.9% (p<0.05) higher than in control. However, when studying the ALT/AST ratio and the Matsuda index, no correlation was found. Thus, in order to assess the development of insulin resistance, appropriate indices have been proposed, the calculation of which is based on data on carbohydrate and lipid metabolism and which complement the data on the pathogenesis of this condition. However, in horses, the choice of a method for studying insulin resistance requires a thorough study.