What question did this study set out to answer?

To investigate whether fetal and maternal plasma concentrations of angiotensin (1-7) and angiotensin II correlate with the risk of preterm birth.

June 29, 2014Journal of Hypertension

Fetal and maternal angiotensin (1-7) are associated with preterm birth

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Pregnancy (n=309). Intervention: Maternal and fetal angiotensin (1-7) plasma concentrations vs. Higher concentrations. Primary outcome: Preterm birth (<37 gestational weeks) (p=0.013).

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Key result

Lower concentrations of maternal (P=0.013) and fetal (P=0.032) plasma angiotensin (1-7) were independently associated with preterm birth.

Why the study?

Are maternal and fetal plasma Ang (1-7) concentrations associated with preterm birth in pregnant women?

Population

309 pregnant women, divided into preterm birth and full-term birth

Design

Cohort

Follow-up

until birth

Authors

YCYoupeng ChenSun Yat-sen University YLYong-Ping LuSun Yat-sen University JLJian LiPeking University Shenzhen Hospital

Discussion

Member takes

Implication

May identify preterm birth risk biomarker; leaves open causal role of Ang (1-7) and need for prospective trials.

Key Points

To investigate whether fetal and maternal plasma concentrations of angiotensin (1-7) and angiotensin II correlate with the risk of preterm birth.
Prospective cohort study of 309 pregnant women grouped into preterm delivery (<37 gestational weeks, n = 17) and full-term delivery (≥37 gestational weeks, n = 292).
Maternal venous blood and neonatal umbilical cord blood were collected at delivery to measure plasma concentrations of Ang (1-7) and Ang II.
Multivariable logistic regression analysis was conducted to assess independent predictors of preterm birth while controlling for confounding clinical factors.
Fetal and maternal Ang (1-7) concentrations were significantly lower in the preterm group compared to term controls (fetal: 486.15 ± 337.34 vs. 833.84 ± 698.12 ng/l; maternal: 399.86 ± 218.93 vs. 710.34 ± 598.22 ng/l).
Multiple logistic regression identified lower maternal Ang (1-7) (P = 0.013), lower fetal Ang (1-7) (P = 0.032), preeclampsia (P < 0.001), and premature rupture of membranes (P = 0.001) as independent risk factors for preterm birth.
The maternal Ang (1-7)/Ang II ratio was independently associated with gestational hypertension and preeclampsia.

Study Design

Type

Cohort (n=309)

Structured PICO

Are maternal and fetal plasma Ang (1-7) concentrations associated with preterm birth in pregnant women?

Population

309 pregnant women prospectively evaluated for the association between maternal and fetal angiotensin (1-7) concentrations and preterm birth.

Exposure

Maternal and neonatal plasma Ang (1-7) and Ang II concentrations

Outcome

Preterm birth (<37 gestational weeks)

Main Result

p-value: p=0.013

Lower maternal and fetal plasma concentrations of Ang (1-7) are independently associated with preterm birth, which is a known risk factor for hypertension later in life.

Cite This Study

Chen et al. (2014) conducted a cohort in Pregnancy (n=309). Maternal and fetal angiotensin (1-7) plasma concentrations vs. Higher concentrations was evaluated on Preterm birth (<37 gestational weeks) (p=0.013). Lower concentrations of maternal (P=0.013) and fetal (P=0.032) plasma angiotensin (1-7) were independently associated with preterm birth.

synapsesocial.com/papers/6a734037feeedbd807c23457 https://doi.org/10.1097/hjh.0000000000000251

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Fetal and maternal angiotensin (1-7) are associated with preterm birth

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Fetal and maternal angiotensin (1-7) are associated with preterm birth

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider