Why the study?
With the increasing prevalence of COPD, understanding the impact of cardiovascular risk on COPD progression is important to guide clinical medication and patient care.
Does a worsening COPD phenotype increase the risk of subclinical atherosclerosis in patients with COPD?
Cohort
Does a worsening COPD phenotype increase the risk of subclinical atherosclerosis in patients with COPD?
Effect estimate: nearly three times
Frequent exacerbations of COPD are associated with a significantly increased risk of subclinical atherosclerosis, particularly in younger patients, suggesting a need for aggressive vascular risk factor management in this population.
Purpose: As the number of patients with chronic obstructive pulmonary disease continues to increase, it is increasingly important to understand the impact of cardiovascular risk on the progression of chronic obstructive pulmonary disease, which can provide guidance for clinical medication and recommendations for patient care and rehabilitation. The purpose of this study was to investigate the relationship between cardiovascular risk and the progression of chronic obstructive pulmonary disease (COPD). Methods: Selected COPD patients admitted to hospital from June 2018 to July 2020 were included in the study for prospective analysis, and patients who showed more than two instances of moderate deterioration or severe deterioration within one year before the consultation were defined as COPD patients, and all participants underwent relevant tests and assessments. Results: Multivariate correction analysis showed that a worsening phenotype improved the risk of carotid artery intima-media thickness exceeding 75% by nearly three times, and it had no relation with the degree of COPD severity and global cardiovascular risk; in addition, the relationship between a worsening phenotype and high carotid intima-media thickness (c-IMT) was more pronounced in patients under 65 years of age. Conclusions: The existence of subclinical atherosclerosis is individually related to the worsening phenotype, and the difference is more obvious in young patients. Therefore, the control of vascular risk factors in these patients should be strengthened.
No takes yet. Share an insight, caveat, or question.
Dai et al. (2023) conducted a cohort in Chronic Obstructive Pulmonary Disease (COPD). Worsening phenotype (>2 instances of moderate or severe deterioration within one year) was evaluated on Carotid artery intima-media thickness exceeding 75% (nearly three times).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: