Among cognitively impaired elderly subjects with atrial fibrillation, low or high ventricular rate response (<50 or >90 bpm) strongly predicted incident dementia (HR 7.70; 95% CI 1.10-14.20; P=0.03).
Cohort (n=358)
Does low or high ventricular rate response predict dementia in cognitively impaired elderly subjects with atrial fibrillation?
In cognitively impaired elderly patients with atrial fibrillation, extreme ventricular rates (<50 or >90 bpm) strongly predict the development of dementia over 10 years.
Hazard Ratio: 7.7 (95% CI 1.1–14.2)
p-value: p=0.03
BACKGROUND: The role of ventricular rate response (VRr) on the incidence of dementia in elderly subjects with cognitive impairment and atrial fibrillation (AF) is not known. Thus, we examined the ability of VRr to predict dementia in cognitively impaired elderly subjects with and without AF. METHODS: A total of 358 cognitively impaired elderly subjects (MMSE 90) and moderate (>50/90 bpm) is predictive of dementia in the presence (HR = 7.70, 95% CI = 1.10-14.20, p = 0.03) but not in the absence (HR = 1.85; 95% CI = 0.78-4.47; p = 0.152) of AF. CONCLUSIONS: This study demonstrates that AF predicts dementia in elderly subjects with cognitive impairment. Moreover, VRr seems to play a key role in the incidence of dementia in cognitively impaired elderly subjects with AF.
Cacciatore et al. (2012) conducted a cohort in Cognitive impairment and atrial fibrillation (n=358). Low/high ventricular rate response (<50/>90 bpm) vs. Moderate ventricular rate response (>50/<90 bpm) was evaluated on Incidence of dementia (HR 7.70, 95% CI 1.10-14.20, p=0.03). Among cognitively impaired elderly subjects with atrial fibrillation, low or high ventricular rate response (<50 or >90 bpm) strongly predicted incident dementia (HR 7.70; 95% CI 1.10-14.20; P=0.03).