Key result
Baseline atrial fibrillation was associated with a significantly increased risk of incident dementia overall (OR 2.0; 95% CI 1.4 to 2.7; p < 0.0001), particularly in patients with stroke.
Why the study?
Is baseline atrial fibrillation associated with an increased incidence of dementia?
Population
15 prospective studies covering 46,637 participants, mean age 71.7 years.
Comparison
Baseline atrial fibrillation vs No baseline atrial fibrillation
Design
Meta-analysis
Authors
Loading...
AF associated with incident dementia in prospective data; leaves open whether anticoagulation or rhythm control modifies risk.
Meta-Analysis (n=46,637)
Is baseline atrial fibrillation associated with an increased incidence of dementia?
Odds Ratio: 2 (95% CI 1.4–2.7)
p-value: p=< 0.0001
Baseline atrial fibrillation is associated with a significantly increased risk of incident dementia, particularly in patients with a history of stroke.
Kwok et al. (2011) conducted a meta-analysis in Atrial fibrillation (n=46,637). Atrial fibrillation vs. No atrial fibrillation was evaluated on Incident dementia overall (OR 2.0, 95% CI 1.4 to 2.7, p=< 0.0001). Baseline atrial fibrillation was associated with a significantly increased risk of incident dementia overall (OR 2.0; 95% CI 1.4 to 2.7; p < 0.0001), particularly in patients with stroke.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: