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A novel amphiphilic camptothecin prodrug, CPT-ss-Ir, consisting of CPT, Ir and a disulfide bond linker, was synthesized, and it could self-assemble into nanowires in aqueous solution. Upon intracellular triggering, active CPT and Ir species were released to exert a considerable anticancer effect.
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He et al. (2016) studied this question.
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