Key result
Percutaneous needle biopsy yields viable cardiac tissue functionally comparable to conventional slices in canine models.
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This paper describes the use of needle biopsy of the heart as a method of obtaining specimens of cardiac muscle for biochemical study in the intact Unanesthetized dog. The procedure is simple and may be repeated many times. Studies indicate that tissue obtained by this method resembles conventional heart slices in its behavior in vitro. Included are data on respiration and the effect of digitalis on cardiac glycogen stores.
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Casten et al. (1953) studied Cardiac metabolism in intact unanesthetized dogs. Needle biopsy of the heart (with digitalis evaluation) vs. Conventional heart slices was evaluated on In vitro tissue respiration and cardiac glycogen stores. Needle biopsy of the heart in intact unanesthetized dogs yielded cardiac muscle specimens that resembled conventional heart slices in their in vitro biochemical behavior.
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