Engineering exosomes and their application in cardiovascular field: Bibliometric analysis from 2002 to 2022

Fig. 1. Flowchart of literature selection All the data were collected from Web of Science Core Collection and underwent analyzing with bibliometrics software CiteSpace and VOSviewer.

Fig. 2. Trends of engineered exosomes and their related studies in cardiovascular field published over the past 20 years The number of studies on engineered exosomes and their related studies in cardiovascular field were shown as blue and red column respectively. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Fig. 3. Network of publications from different countries and institutions about engineered exosomes (a) Distribution of national cooperation of engineered exosomes related literatures, containing 53 nodes and 60 connections in the network. (b) Institutional cooperation network of engineered related studies, including 327 nodes and 325 connections in the network. Especially, the number of documents by different countries and institutions as well as their inter-cooperation were shown as nodes and line respectively. The size of these nodes was positively connected with the number of published literatures.

Fig. 4. The visualization map of authors and co-cited authors involved in engineered exosomes & cardiovascular field (a) The cooperative network of authors existed in “engineered exosomes & cardiovascular studies” related articles. (b) The co-citation of authors.

Fig. 5. Visualization map of keywords clustering on engineered exosomes This map constituted by 90 items, including red clusters (32 items), green clusters (30 items) and blue clusters (28 items). Especially, the size of nodes in this map was positively correlated with the frequency of keywords. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Fig. 6. Keywords clustering map of engineered exosomes & cardiovascular studies 90 items were shown through 6 colors respectively in this visualization map. Especially, 1452 connecting lines occurred and the total connection strength was 2456. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Fig. 7. The top 25 outbreak citation keywords involved in engineered exosomes & cardiovascular studies The burst analysis of keywords in engineered exosomes & cardiovascular related studies showed that four keywords such as repair, myocardial apoptosis, brain, and microcystic vesicles, were in the citation outbreak since 2020.

Fig. 8. Visualization timeline map of engineered exosomes & cardiovascular studies In the map, the X-axis was the published year of keywords Y-axis was the cluster number, which could show the time span and research process of each cluster.