What question did this study set out to answer?

To investigate the pharmacokinetics, oral absorption in fed and fasted states, and physiological safety of cannabigerol (CBG) and cannabigerolic acid (CBGA) in dogs.

March 4, 2022Journal of Veterinary Pharmacology and Therapeutics

Single dose and chronic oral administration of cannabigerol and cannabigerolic acid‐rich hemp extract in fed and fasted dogs: Physiological effect and pharmacokinetic evaluation

View Full Paper

Ask AI

Bookmark

Authors

KAKara Amstutz WSWayne S. SchwarkCornell University AZAlexander ZakharovUniversity of Illinois Chicago

Discussion

Member takes

Implication

Pharmacokinetic study reveals superior absorption of cannabigerolic acid over cannabigerol in dogs, indicating potential utility for safe veterinary cannabinoid therapies.

Key Points

To investigate the pharmacokinetics, oral absorption in fed and fasted states, and physiological safety of cannabigerol (CBG) and cannabigerolic acid (CBGA) in dogs.
Administered single and chronic oral doses of hemp extract containing equal quantities of CBG and CBGA to dogs under both fed and fasted conditions.
Conducted a two-week chronic trial with twice-daily administration of 2 mg/kg in fasted and fed states.
Evaluated physiological safety via serial physical examinations, complete blood counts, and serum chemistry profiles.
CBGA exhibited approximately 40-fold greater oral absorption than CBG regardless of whether administered in fed or fasted states.
Twice-daily dosing at 2 mg/kg yielded stable mean serum concentrations of 5 ng/ml for CBG and 250 ng/ml for CBGA, with no differences observed between fed and fasted states.
No adverse events were observed across the two-week study period based on physical examinations, complete blood counts, and serum chemistry panels.

Cite This Study

Amstutz et al. (2022) studied this question.

synapsesocial.com/papers/6a734650fa34ce6ab0c8f901 https://doi.org/10.1111/jvp.13048

View Full Paper

Ask AI

Bookmark

Implication

Pharmacokinetic study reveals superior absorption of cannabigerolic acid over cannabigerol in dogs, indicating potential utility for safe veterinary cannabinoid therapies.

Single dose and chronic oral administration of cannabigerol and cannabigerolic acid‐rich hemp extract in fed and fasted dogs: Physiological effect and pharmacokinetic evaluation

Discussion

Member takes

Implication

Key Points

Cite This Study

Single dose and chronic oral administration of cannabigerol and cannabigerolic acid‐rich hemp extract in fed and fasted dogs: Physiological effect and pharmacokinetic evaluation

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider