Simulation of Blood Pressure Control Operations in a Heart-Blood Vessel System

This paper presents a simulation model on the rapid restoration of arterial pressure, which is useful for analyzing abnormal blood-pressure drops on the hemorrhagic shock.In the present model, the compartments considered are a heart-blood vessel system and a nerve center system. The heart-blood vessel system is represented based on electrical equivalent circuits. The nerve center system, which is composed of a carotid sinus baroreflex system, a vagally-mediated system and a facilitatory interacting system, is represented based on several control elements such as a first-order element, a dead time element and a saturation element.In order to verify availabilities of the present model, some calculation results of simulation are examined by the experimental results of arterial pressure response within 1∼2 minutes after a quick mild 10% hemorrhage on conscious dogs The result of examination is as follows:(1) The characteristics of static response coincide well with the experimental results.(2) The characteristics of dynamic response do not coincide well with those of the experiment. This is because of difficulties of the determination of some parameters on the carotid sinus baroreflex system.