Key result
A multiscale closed-loop cardiovascular model was developed and its performance demonstrated in simulating neurogenic hypertension and acute 10% hemorrhage.
A novel multiscale closed-loop cardiovascular model can simulate autonomic responses to stressors like hemorrhage and hypertension.
May support in silico testing of autonomic cardiovascular responses; leaves open clinical translation pending validation.
A computational tool is developed for simulating the dynamic response of the human cardiovascular system to various stressors and injuries. The tool couples 0-dimensional models of the heart, pulmonary vasculature, and peripheral vasculature to 1-dimensional models of the major systemic arteries. To simulate autonomic response, this multiscale circulatory model is integrated with a feedback model of the baroreflex, allowing control of heart rate, cardiac contractility, and peripheral impedance. The performance of the tool is demonstrated in 2 scenarios: neurogenic hypertension by sustained stimulation of the sympathetic nervous system and an acute 10% hemorrhage from the left femoral artery.
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Canuto et al. (2018) studied Hemorrhage and hypertension (simulated). Multiscale closed-loop cardiovascular model was evaluated on Simulation of neurogenic hypertension and acute 10% hemorrhage. A multiscale closed-loop cardiovascular model was developed and its performance demonstrated in simulating neurogenic hypertension and acute 10% hemorrhage.
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