March 1, 1990AJP Renal Physiology
Identification of individual renocortical cells that secrete renin
Population
Individual renocortical cells (juxtaglomerular cells)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Validates single-cell renin secretion assay in animals; leaves open translation to human physiology or therapy.
Structured PICO
P
Population
Individual renocortical cells (juxtaglomerular cells)
I
Intervention
Reverse hemolytic plaque assay, beta-adrenergic stimulation, and extracellular calcium
O
Outcome
Identification of individual renin-secreting cells and changes in renin secretionsurrogate
The development of a reverse hemolytic plaque assay allows for the precise identification and study of individual renin-secreting juxtaglomerular cells.
Cite This Study
Carey et al. (1990) studied this question.