Key result
ACE inhibition with enalapril increased the number of renin-secreting cells by over 15-fold and induced a 3-fold increase in the amount of renin released in rat models.
Population
Fetal and adult rats
Comparison
ACE inhibition with enalapril in the presence… vs Baseline / absence of ACE inhibition
Design
Preclinical
Follow-up
7 days
Authors
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Renin gene responses to ACE inhibition in rats may extend prior whole-kidney data; leaves open human transcriptional mechanisms.
ACE inhibition stimulates renin mRNA accumulation and increases both the number of renin-secreting cells and the amount of renin secreted per cell, reverting adult renal vessels to a fetal-like state.
Ice et al. (1988) studied Renin secretion. Enalapril (ACE inhibition) vs. Absence of ACE inhibition / Angiotensin II co-administration was evaluated on Number of renin secreting cells and amount of renin released. ACE inhibition with enalapril increased the number of renin-secreting cells by over 15-fold and induced a 3-fold increase in the amount of renin released in rat models.
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