Why the study?
Does enalapril or sodium depletion increase renin secretion in adult Wistar-Kyoto rats?
Does enalapril or sodium depletion increase renin secretion in adult Wistar-Kyoto rats?
ACE inhibition with enalapril increases renin secretion primarily by recruiting additional renin-secreting cells, whereas sodium depletion increases both cell recruitment and secretion per cell equally.
No takes yet. Share an insight, caveat, or question.
Findings in rats should not change ACEi practice; extends mechanistic insights into renin cell recruitment.
Geary et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: