Key result
Composite endpoints can enhance study power and precision in clinical trials, but poorly constructed composites with large variations in clinical importance across components can be misleading.
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Composite endpoints in clinical trials can improve statistical efficiency but risk misleading conclusions if components vary widely in clinical importance and frequency.
Myles et al. (2010) conducted a review in Anesthesia and perioperative care. Composite endpoints was evaluated. Composite endpoints can enhance study power and precision in clinical trials, but poorly constructed composites with large variations in clinical importance across components can be misleading.
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